FiftyYearsofResearchinARDS.Setting Positive End-Expiratory Pressure in Acute Respiratory Distress Syndrome

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Fifty Years of Research in ARDS. Setting Positive End-Expiratory Pressure in Acute Respiratory Distress Syndrome.

Positive end-expiratory pressure (PEEP) has been used during mechanical ventilation since the first description of acute respiratory distress syndrome (ARDS). In the subsequent decades, many different strategies for optimally titrating PEEP have been proposed. Higher PEEP can improve arterial oxygenation, reduce tidal lung stress and strain, and promote more homogenous ventilation by preventing...

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Lung emptying in patients with acute respiratory distress syndrome: effects of positive end-expiratory pressure.

The pattern of lung emptying was studied in 10 mechanically-ventilated patients with acute respiratory distress syndrome. At four levels of positive end-expiratory pressure (PEEP) (0, 5, 10 and 15 cmH2O) tracheal (Ptr) and airway pressures (Paw), flow (V') and volume (V) were continuously recorded. Tidal volume was set between 0.5-0.6 L and V'/V curves during passive expiration were obtained. E...

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Variable Effect of Positive End-expiratory Pressure on Oxygenation in Patients with Acute Respiratory Distress Syndrome

To the Editor:—The recent article by Thille et al. and the accompanying editorial by Rouby discuss the effects of positive end-expiratory pressure (PEEP) on pulmonary recruitability in patients with adult respiratory distress syndrome (ARDS). Thille et al. found that alveolar recruitment was similar in pulmonary and extrapulmonary ARDS and concluded that PEEP levels should not be determined bas...

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Effects of positive end-expiratory pressure on gastric mucosal perfusion in acute respiratory distress syndrome

INTRODUCTION Positive end-expiratory pressure (PEEP) improves oxygenation and can prevent ventilator-induced lung injury in patients with acute respiratory distress syndrome (ARDS). Nevertheless, PEEP can also induce detrimental effects by its influence on the cardiovascular system. The purpose of this study was to assess the effects of PEEP on gastric mucosal perfusion while applying a protect...

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Compressive forces and computed tomography-derived positive end-expiratory pressure in acute respiratory distress syndrome.

BACKGROUND It has been suggested that higher positive end-expiratory pressure (PEEP) should be used only in patients with higher lung recruitability. In this study, the authors investigated the relationship between the recruitability and the PEEP necessary to counteract the compressive forces leading to lung collapse. METHODS Fifty-one patients with acute respiratory distress syndrome (7 mild...

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ژورنال

عنوان ژورنال: American Journal of Respiratory and Critical Care Medicine

سال: 2017

ISSN: 1073-449X,1535-4970

DOI: 10.1164/rccm.201610-2035ci